Current research on carbetocin and implications for prevention of postpartum haemorrhage
نویسندگان
چکیده
منابع مشابه
Prevention of postpartum haemorrhage with the oxytocin analogue carbetocin.
Postpartum haemorrhage is the leading cause of maternal mortality worldwide: 67-80% of cases are caused by uterine atony. Preventive measures include prophylactic drug use to aid uterine contraction after delivery, thus avoiding severe blood loss and reducing maternal morbidity and mortality. Carbetocin is a synthetic analogue of oxytocin with a half-life approximately 4-10 times longer than th...
متن کاملAdverse Effects of Carbetocin versus Oxytocin in the Prevention of Postpartum Haemorrhage after Caesarean Section: A Randomized Controlled Trial
Purpose To compare the incidence of nausea, vomiting, and arterial hypotension between carbetocin and oxytocin to prevent haemorrhage after caesarean section (CS). Methods A randomized controlled trial in term pregnant women undergoing planned CS. Groups were randomized to carbetocin or oxytocin. Blood pressure (BP), heart rate, presence of nausea/vomitus, and need for vasopressors were evalu...
متن کاملTranexamic acid for the prevention and treatment of postpartum haemorrhage.
Postpartum haemorrhage (PPH) is a major cause of maternal mortality, accounting for one-quarter of all maternal deaths worldwide. Uterotonics after birth are the only intervention that has been shown to be effective for PPH prevention. Tranexamic acid (TXA), an antifibrinolytic agent, has therefore been investigated as a potentially useful complement to this for both prevention and treatment be...
متن کاملHaemostatic monitoring during postpartum haemorrhage and implications for management
Postpartum haemorrhage (PPH) is a major risk factor for maternal morbidity and mortality. PPH has numerous causative factors, which makes its occurrence and severity difficult to predict. Underlying haemostatic imbalances such as consumptive and dilutional coagulopathies may develop during PPH, and can exacerbate bleeding and lead to progression to severe PPH. Monitoring coagulation status in p...
متن کاملCarbetocin vs. Syntometrine in Prevention of Postpartum Hemorrhage: a Double Blind Randomized Control Trial
BACKGROUND Postpartum hemorrhage is a significant cause of maternal mortality and morbidity, worldwide. OBJECTIVES The aim of this study was to compare the efficacy between carbetocin and syntometrine in prevention of postpartum hemorrhage. MATERIALS AND METHODS This study was a double blind randomized clinical trial that carried out on 200 pregnant women referred to Shabiehkhani maternity c...
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ژورنال
عنوان ژورنال: Reproductive Health
سال: 2018
ISSN: 1742-4755
DOI: 10.1186/s12978-018-0529-0